Publications

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Camp D, Venkatesh B, Solianova V, Varela L, Goult BT, Tanentzapf G. The actin binding sites of talin have both distinct and complementary roles in cell-ECM adhesion. PLoS Genet. 2024 Apr 25;20(4):e1011224. doi: 10.1371/journal.pgen.1011224. Epub ahead of print. PMID: 38662776.

David SB, Ho KYL, Tanentzapf G, Zaritsky A. Formation of recurring transient Ca2+-based intercellular communities during Drosophila hematopoiesis. Proc Natl Acad Sci U S A. 2024 Apr 16;121(16):e2318155121. doi: 10.1073/pnas.2318155121. Epub 2024 Apr 11. PMID: 38602917; PMCID: PMC11032476.

Ho KYL, An K, Carr RL, Dvoskin AD, Ou AYJ, Vogl W, Tanentzapf G. Maintenance of hematopoietic stem cell niche homeostasis requires gap junction-mediated calcium signaling. Proc Natl Acad Sci U S A. 2023 Nov 7;120(45):e2303018120. doi: 10.1073/pnas.2303018120. Epub 2023 Oct 30. PMID: 37903259; PMCID: PMC10636368.

Ho KYL, Carr RL, Dvoskin AD, Tanentzapf G. Kinetics of blood cell differentiation during hematopoiesis revealed by quantitative long-term live imaging. Elife. 2023 Mar 31;12:e84085. doi: 10.7554/eLife.84085. PMID: 37000163; PMCID: PMC10065797.

Haage A, Tanentzapf G. Analysis of Integrin-Dependent Melanoblast Migration During Development. Methods Mol Biol. 2023;2608:207-221. doi: 10.1007/978-1-0716-2887-4_13. PMID: 36653710.

Pesch YY, Dang V, Fairchild MJ, Islam F, Camp D, Kaur P, Smendziuk CM, Messenberg A, Carr R, McFarlane CR, Musso PY, Van Petegem F, Tanentzapf G. Gap junctions mediate discrete regulatory steps during fly spermatogenesis. PLoS Genet. 2022 Sep 29;18(9):e1010417. doi: 10.1371/journal.pgen.1010417. PMID: 36174062; PMCID: PMC9578636.

Urtatiz O, Haage A, Tanentzapf G, Van Raamsdonk CD. Crosstalk with keratinocytes causes GNAQ oncogene specificity in melanoma. Elife. 2021 Dec 23;10:e71825. doi: 10.7554/eLife.71825. PMID: 34939927; PMCID: PMC8747508.

Ho KYL, Khadilkar RJ, Carr RL, Tanentzapf G. A gap-junction-mediated, calcium-signaling network controls blood progenitor fate decisions in hematopoiesis. Curr Biol. 2021 Nov 8;31(21):4697-4712.e6. doi: 10.1016/j.cub.2021.08.027. Epub 2021 Sep 3. PMID: 34480855.

Khadilkar RJ, Ho KYL, Venkatesh B, Tanentzapf G. Integrins Modulate Extracellular Matrix Organization to Control Cell Signaling during Hematopoiesis. Curr Biol. 2020 Sep 7;30(17):3316-3329.e5. doi: 10.1016/j.cub.2020.06.027. Epub 2020 Jul 9. PMID: 32649911.

Haage A, Wagner K, Deng W, Venkatesh B, Mitchell C, Goodwin K, Bogutz A, Lefebvre L, Van Raamsdonk CD, Tanentzapf G. Precise coordination of cell-ECM adhesion is essential for efficient melanoblast migration during development. Development. 2020 Jul 17;147(14):dev184234. doi: 10.1242/dev.184234. PMID: 32580934.

Fu L, Haage A, Kong N, Tanentzapf G, Li H. Dynamic protein hydrogels with reversibly tunable stiffness regulate human lung fibroblast spreading reversibly. Chem Commun (Camb). 2019 May 8;55(36):5235-5238. doi: 10.1039/c9cc01276a. Epub 2019 Apr 15. PMID: 30984936.

Khadilkar R.J., Tanentzapf G. (2019). Septate junction components control Drosophila hematopoiesis through the Hippo pathway. Development. Apr 4;146(7). pii: dev166819

Fu L., Haage A., Kong N., Tanentzapf G., Li H. (2019). Dynamic protein hydrogels with reversibly tunable stiffness regulate human lung fibroblast spreading reversibly. Chem Commun (Camb). 2019 May 8;55(36):5235-5238

Fei Z., Bae K., Parent S.E., Wan H., Goodwin K.G., Theisen U., Tanentzapf G., Bruce A.E.E.. (2019) A cargo model of yolk syncytial nuclear migration during zebrafish epiboly. Development. Jan 2;146(1). pii: dev169664

Camp D., Haage A., Solianova V., Castle W.M., Xu A.A., Lostchuck W., Goult B.T., Tanentzapf G. (2018) Direct binding of Talin to Rap1 is required for cell–ECM adhesion in Drosophila.  Journal of Cell Science. 131: jcs225144 doi: 10.1242/jcs.225144

Haage A., Goodwin K.G.,Whitewood A., Bogutz A., Lefebvre L., Plotnikov S., Goult B.T., Tanentzapf G. (2018) Talin autoinhibition regulates cell-ECM adhesion dynamics and wound healing in vivo. Cell Reports, 25, 2401–2416

Fairchild M.J.,Islam F.,Tanentzapf G.(2017) Identification of genetic networks that act in the somatic cells of the testis to mediate the developmental program of spermatogenesis. PLOS Genetics.13(9):e1007026.doi:10.1371/journal.pgen.1007026

Khadilkar R.J., Vogl W., Goodwin K., Tanentzapf G.†(2017) Modulation of occluding junctions alters the hematopoietic niche to trigger immune activation. Elife. 2017 Aug 25;6. pii: e28081. doi: 10.7554/eLife.28081.

Goodwin K..§, Lostchuck E.E..§, Cramb K.M.,Zulueta-Coarasa T., Fernandez-Gonzalez R., Tanentzapf G.†(2017) Cell-cell and cell-ECM adhesions cooperate to organize actomyosin networks and maintain force transmission during Dorsal Closure. Molecular Biology of the Cell. 28(10):1301-1310. doi: 10.1091/mbc.E17-01-0033

Goodwin K.E.§, Ellis S.J.1§, Lostchuck E.§,Zulueta-Coarasa T., Fernandez-Gonzalez R., Tanentzapf G G.† (2016) Basal Cell-Extracellular Matrix Adhesion Regulates Force Transmission during Tissue Morphogenesis. Developmental Cell. 39(5):611-625. doi: 10.1016/j.devcel.2016.11.003.

Fairchild M.J., Yang L., Goodwin K.,Tanentzapf G. (2016) Occluding Junctions Maintain Stem Cell Niche Homeostasis in the Fly Testes. Current Biology.26(18):2492-9. doi: 10.1016/j.cub.2016.07.012.

López-Ceballos P., Herrera-Reyes A.D., Coombs D., Tanentzapf G.†(2016) In vivo regulation of integrin turnover by outside-in activation. Journal of Cell Science, 129(15):2912-24. doi: 10.1242/jcs.190256.

Hákonardóttir G.K.§, López-Ceballos P.§, Herrera-Reyes A.D., Das R., Coombs D., Tanentzapf G.†(2015) In vivo quantitative analysis of Talin turnover in response to force. Molecular Biology of the Cell. 2015 26(22):4149-62. doi: 10.1091/mbc.E15-05-0304. 

Smendziuk C.M.,Messenberg A., Vogl A.W., Tanentzapf G.†(2015) Bi-directional gap junction-mediated soma-germline communication is essential for spermatogenesis. Development. 142(15):2598-609. doi: 10.1242/dev.123448.

Fairchild M.J., Smendziuk C.M.,Tanentzapf G†(2015) A somatic permeability barrier around the germline is essential for Drosophila spermatogenesis. Development.Jan 15;142(2):268-81. doi: 10.1242/dev.114967

Cetera M., Ramirez-San Juan G.R., Oakes P.W., Lewellyn L., Fairchild M.J.,Tanentzapf G., Gardel M.L., Horne-Badovinac S. (2014) Epithelial rotation promotes the global alignment of contractile actin bundles during Drosophila egg chamber elongation. Nature Communications. doi: 10.1038/ncomms6511.

Ellis S.J., Lostchuck E.,Goult B.T., Bouaouina M., Fairchild M.J., López-Ceballos P., Calderwood D.A., Tanentzapf G.† (2014).The talin head domain reinforces integrin-mediated adhesion by promoting adhesion complex stability and clustering. PLOS Genetics, doi: 10.1371/journal.pgen.1004756.

Perkins A.D., Lee M.J.J., Tanentzapf G.†(2014) The systematic identification of cytoskeletal genes required for Drosophila melanogaster muscle maintenance. Scientific Data. 1:140002. doi:10.1038/sdata.2014.2

Perkins A.D., Tanentzapf G.†(2014) An ongoing role for structural sarcomeric components in maintaining Drosophila melanogaster muscle function and structure. PLOS One10;9(6):e99362. doi: 10.1371/journal.pone.0099362.

Ellis S.J, Goult B.T., Fairchild M.J.,Harris N.J.,Long J., Czerniecki S., Lobo P., Van Petegem F., Schoeck F., Peifer M., Tanentzapf G.†. (2013) Talin autoinhibition is required for morphogenesis. Current Biology. 23:1825-1833.

Bouaouina M., Jani K., Czerniecki S., Long J.Y., Ellis S.J.,Tanentzapf G., Calderwood D.A., Schöck F. (2012) Zasp regulates integrin activation. Journal of Cell Science.125:5647-5657.

Pines M., Das R., Ellis S.J., Morin A., Czerniecki S., Yuan L., Klose M., Coombs D., Tanentzapf G.† (2012) Mechanical force regulates integrin turnover in Drosophila in vivo. Nature Cell Biology.14:935-943 

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Ellis S.J., Pines M.,Fairchild M.J., Tanentzapf G.†(2011) In vivofunctional analysis reveals specific roles for the integrin binding sites of talin.  Journal of Cell Science. 124:1844-1856.  

Ribeiro I., Yuan L., Tanentzapf G., Dowling J.J., Kiger A. (2011) Phosphoinositide regulation of integrin trafficking required for muscle attachment and maintenance.  PloS Genetics, 10:7(2):e1001295.

Pines M., Fairchild M.J., Tanentzapf G.†(2011) Distinct regulatory mechanisms control integrin adhesive processes during tissue morphogenesis.  Developmental Dynamics. 240:36-51.

Yuan L., Fairchild M.J., Perkins A.D.,Tanentzapf G.†(2010) Analysis of integrin turnover in fly myotendinous junctions.  Journal of Cell Science 123:939-946.

Perkins A.D., Ellis S.J., Asghari P., Shamsian A., Moore E.D., Tanentzapf G.†(2010) Integrin-mediated adhesion maintains the sarcomeric integrity.  Developmental Biology338:15-27.

Franco-Cea A., Ellis S.J.,Fairchild M.J., Yuan L., Cheung T.Y., Tanentzapf G.†(2010) Distinct developmental roles for direct and indirect talin-mediated linkage to actin.  Developmental Biology. 345:64-77. 

Ellis S.J., Tanentzapf G.†(2010) Integrin-mediated adhesion and stem-cell-niche interactions.  Cell and Tissue Research. 339:121-30. 

Cheung T.Y., Fairchild M.J., Zarivach R., Tanentzapf G.†,Van Petegem F (2009) Crystal Structure of the Talin Integrin Binding Domain 2.  Journal of Molecular Biology. 387:787-793.

Tanentzapf G.†, Devenport D.N., Godt D., Brown N.H. (2007) Integrin- dependent anchoring of a stem cell niche.  Nature Cell Biology. 9:1413-1418. 

Le T., Liang Z., Patel H, Yu M.H., Sivasubramaniam G., Slovitt M., Tanentzapf G., Mohanty N, Paul S.M., Wu V.M., Beitel G.J. (2006) A New Family of Drosophila Balancer Chromosomes With a w-dfd-GMR YFP Marker. Genetics. 174:2255-2257. 

Tanentzapf G.,Brown N.H. (2006) An interaction between integrin and the talin FERM domain mediates integrin activation but not linkage to the cytoskeleton. Nature Cell Biology. 8:601-606.

Tanentzapf G., Martin-Bermudo M.D., Hicks M.S., Brown N.H. (2006) Multiple factors contribute to integrin-talin interactions in vivo.  Journal of Cell Science119:1632-1644.  

Bécam I.E., Tanentzapf G., Lepesant, J.A., Brown N.H., Huynh J.R. (2005) Integrin-independent repression of cadherin transcription by talin during axis formation in Drosophila. Nature Cell Biology :510-516.  

Tanentzapf G.,Tepass U. (2003) Interactions between the crumbs, lethal giant larvae and bazooka pathways in epithelial polarization.  Nature Cell Biology, 5:46-52.  

Pellikka M.§,Tanentzapf G., Pinto M, Smith C., McGlade C.J., Ready D.F., Tepass U. (2002) Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis.  Nature,416:143-149. 

Tepass U., Tanentzapf G., Ward R., Fehon R. (2001) Epithelial cell polarity and cell junctions in Drosophila.  Annual Review of Genetics. 35:747-84.

Tanentzapf G.,Smith C., McGlade J., Tepass U. (2000) Apical, lateral, and basal polarization cues contribute to the development of the follicular epithelium during Drosophila oogenesis. Journal of Cell Biology. 151:891-904.